Doc2b ∞ Area

Doc2b

Meaning

Doc2b refers to Double C2-like Domain Containing Protein Beta, a neuronal and neuroendocrine protein that plays a significant role in calcium-dependent exocytosis. This protein functions as a calcium sensor, facilitating the precise release of various substances from vesicles within cells. Its activity is essential for maintaining proper cellular communication and physiological responses.

Context

Within the human body, Doc2b is prominently expressed in the central nervous system and in endocrine tissues, including the pancreatic beta cells, adrenal medulla, and pituitary gland. Its presence in these specialized cells underscores its involvement in the regulated secretion of neurotransmitters, hormones, and other signaling molecules. This protein contributes to the regulatory mechanisms governing physiological functions.

Significance

Understanding Doc2b’s function is clinically important for conditions involving regulated secretion, such as diabetes mellitus or certain neurological disorders. Dysregulation of Doc2b could impact insulin release from pancreatic beta cells, affecting glucose homeostasis, or alter neurotransmitter secretion, influencing neurological function. Assessing its role can provide insights into disease pathogenesis and potential therapeutic targets.

Mechanism

Doc2b contains C2 domains that bind calcium, enabling it to interact with components of the SNARE complex, which mediates membrane fusion. Upon calcium influx, Doc2b undergoes a conformational change, promoting the docking and fusion of vesicles with the plasma membrane. This action precisely controls the timing and quantity of secreted substances, ensuring a swift and appropriate cellular response.

Application

In research, Doc2b serves as a model for studying calcium-triggered exocytosis and its role in neuroendocrine physiology. Clinically, while not a direct therapeutic target currently, insights into Doc2b’s pathway could inform strategies for managing conditions like type 2 diabetes by optimizing insulin secretion. Its principles are relevant to understanding how various secretagogues influence cellular release processes.

Metric

Direct measurement of Doc2b levels in a clinical setting is not a standard diagnostic practice. However, its functional integrity can be indirectly assessed by evaluating the efficiency of calcium-dependent hormone or neurotransmitter release in relevant cell types. Researchers may use molecular assays like Western blotting or immunohistochemistry to quantify its expression in tissue samples.

Risk

Imbalances or genetic variations affecting Doc2b function could theoretically contribute to secretory dysfunction, though direct clinical risks are not well-defined. Disruptions in its activity might lead to impaired hormone release or neurotransmission, potentially exacerbating underlying metabolic or neurological conditions. Any therapeutic interventions targeting exocytosis would require careful consideration of broader physiological impacts.

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HRTioAugust 3, 2025

Doc2b

Meaning

Context

Significance

Mechanism

Application

Metric

Risk

Are There Lifestyle or Diet Changes That Can Enhance the Beta-Cell Protective Effects of Peptides?

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