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DNMTs

Meaning

DNMTs, or DNA Methyltransferases, are a family of enzymes that catalyze the transfer of a methyl group to DNA, specifically at cytosine bases within CpG dinucleotides. These enzymes are central to the epigenetic machinery, establishing and maintaining patterns of DNA methylation across the genome. This methylation process typically leads to gene silencing, serving as a critical mechanism for regulating gene expression without altering the underlying DNA sequence. DNMT activity is a dynamic process influenced by age, environmental factors, and hormonal signaling.