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DNA Variations

Meaning

DNA variations represent differences in the nucleotide sequence of the deoxyribonucleic acid among individuals, populations, or cell types. These genetic differences include single nucleotide polymorphisms (SNPs), insertions, deletions, and structural changes, which collectively contribute to the vast biological diversity observed in humans. In the context of hormonal health, these variations can significantly impact the expression or function of hormone receptors, metabolic enzymes, and signaling proteins, thereby altering an individual’s response to endogenous hormones or exogenous therapies. Clinical genomics utilizes the mapping of these variations to predict disease risk and personalize treatment strategies.