DNA Repair Stimulation is the targeted biological process of enhancing the efficiency and capacity of the cell’s intrinsic enzymatic machinery to identify, excise, and correct damage to the deoxyribonucleic acid (DNA) sequence. This process is paramount for maintaining genomic stability, preventing cellular senescence, and mitigating the foundational causes of aging and disease. Clinical interventions aim to bolster these natural repair pathways.
Origin
This is a term from molecular biology and genetics, where “DNA Repair” describes the cellular maintenance function, and “Stimulation” refers to the deliberate enhancement of this process. It is a core tenet of modern longevity science.
Mechanism
The mechanism involves activating specific signaling pathways, such as the Sirtuin and PARP pathways, which regulate the activity of DNA repair enzymes like endonucleases and ligases. Hormones, particularly those with antioxidant and anti-inflammatory properties, can indirectly support this process by reducing oxidative stress, a major source of DNA damage. Maintaining optimal levels of cofactors and energy (ATP) is also critical for the high energetic demand of DNA restoration.
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