What is the Origin of DNA Repair Enhancement?

This is a term from molecular genetics and longevity science, combining the foundational molecule of life, "DNA," with the crucial biological process of "repair," and the therapeutic goal of "enhancement." It is a central pillar of modern anti-aging research, recognizing DNA damage as a primary driver of senescence.

What is the Mechanism of DNA Repair Enhancement?

Enhancement can be achieved by providing specific nutritional cofactors, activating key signaling pathways like sirtuins and PARPs, or utilizing small molecules that upregulate the expression of DNA repair enzymes. These interventions support various pathways, including base excision repair, nucleotide excision repair, and double-strand break repair, collectively ensuring the accurate transmission of genetic information during replication and transcription.

DNA Repair Enhancement

Meaning

A clinical or biological strategy focused on increasing the efficiency and capacity of the cellular machinery responsible for correcting molecular lesions and structural damage within the deoxyribonucleic acid (DNA) molecule. Enhancing these repair processes is vital for maintaining genomic integrity, preventing mutations, and slowing down the fundamental processes of cellular aging and carcinogenesis. This is a crucial defense against accumulated damage.