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DNA Methylation Signatures

Meaning

DNA Methylation Signatures represent distinct patterns of chemical modification where a methyl group is covalently added to cytosine bases, predominantly at CpG sites, across the genome. These signatures constitute a key layer of epigenetic information that does not alter the underlying DNA sequence but profoundly regulates gene expression and cellular function. Clinically, specific patterns serve as highly accurate “epigenetic clocks” capable of predicting an individual’s biological age and disease risk.