What is the Origin of DNA Methylation Clock Reversal?

The concept originates from epigenetic research, specifically the development of 'epigenetic clocks' (e.g., Horvath's clock) that correlate methylation sites with chronological age. Reversal denotes the intervention-induced shift in this biological aging metric. It represents a sophisticated endpoint in longevity science.

What is the Mechanism of DNA Methylation Clock Reversal?

Reversal mechanisms are thought to involve modulating the activity of DNA methyltransferases (DNMTs) or influencing the availability of S-adenosylmethionine (SAM), the universal methyl donor. Certain interventions, including specific nutrient supplementation or lifestyle modifications, may influence the epigenetic machinery to reset or slow the accumulation of age-associated methylation changes. This process reflects a restoration of youthful gene expression patterns.

DNA Methylation Clock Reversal ∞ Area

DNA Methylation Clock Reversal

Meaning

DNA Methylation Clock Reversal refers to the measurable biological phenomenon where epigenetic marks, specifically DNA methylation patterns measured by validated aging algorithms, exhibit a reduction in chronological age estimation. This is a key biomarker suggesting successful systemic rejuvenation strategies impacting cellular aging trajectories. Achieving this reversal implies improved epigenetic fidelity.