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DNA Adducts

Meaning

DNA adducts are segments of DNA covalently bound to a cancer-causing or toxic chemical, known as a genotoxic agent or carcinogen. These molecular lesions represent physical damage to the genetic material, potentially altering the DNA sequence or structure and interfering with normal replication and transcription processes. The presence and persistence of specific DNA adducts serve as critical biomarkers of exposure to environmental toxins and endogenous reactive species, such as those generated during oxidative stress or aberrant hormone metabolism. Their accumulation is closely linked to the initiation of mutagenesis and carcinogenesis.