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Diurnal Variance Testing

Meaning

Diurnal Variance Testing is a clinical diagnostic procedure that measures the fluctuating levels of specific hormones, neurotransmitters, or metabolites throughout a 24-hour cycle to assess the integrity of the body’s circadian rhythm and endocrine regulation. This type of testing moves beyond single-point measurements, capturing the critical peak and trough patterns that reflect true physiological function, particularly for stress hormones like cortisol and sex hormones. It is essential for diagnosing conditions rooted in circadian disruption, such as adrenal dysfunction or sleep-wake cycle abnormalities.