The clinical process of precisely measuring and analyzing the cyclical, 24-hour fluctuations of key biological molecules, such as circulating hormones or neurotransmitters, to assess the functional integrity of an individual’s circadian system. This diagnostic tool provides a dynamic temporal profile rather than a single static measurement, revealing critical phase shifts or amplitude blunting. It is essential for personalized chronotherapy.
Origin
This methodology is deeply rooted in chronobiology and clinical chemistry, recognizing that most physiological processes, especially endocrine signaling, operate on a time-of-day dependent schedule. Mapping provides a comprehensive view of these endogenous oscillations, which are vital for maintaining homeostasis.
Mechanism
Testing typically involves collecting serial biological samples, such as saliva or urine, at predefined intervals throughout the day and night to accurately capture the peaks and troughs of analytes like cortisol, melatonin, or sex hormones. The resulting map is then compared against established normative chronotypes to identify dysregulation. This precise data informs targeted interventions aimed at re-establishing optimal rhythmicity.
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