What is the Origin of Diurnal Cortisol Profiling?

The concept is rooted in chronobiology and endocrinology, recognizing that many hormones, especially cortisol, exhibit strong circadian rhythms. Profiling moves beyond a single snapshot, offering a dynamic view of adrenal function over the active day. This assessment is foundational in evaluating the physiological cost of chronic stressors.

What is the Mechanism of Diurnal Cortisol Profiling?

Cortisol secretion is primarily driven by the suprachiasmatic nucleus signaling through the HPA axis, peaking shortly after waking to mobilize energy for the day's activities. Analyzing the profile reveals the axis's ability to properly phase-advance and dampen nocturnal secretion. Impaired signaling, often seen in chronic stress states, results in a flattened curve or inappropriate timing of peak secretion.

Diurnal Cortisol Profiling

Meaning

Diurnal Cortisol Profiling is the clinical practice of measuring cortisol levels at multiple, specific time points throughout a 24-hour cycle to map the natural rise and fall pattern of this key glucocorticoid. This profile provides essential insight into the integrity and responsiveness of the Hypothalamic-Pituitary-Adrenal (HPA) axis. Deviations from the expected morning peak and evening nadir often signify chronic stress or adrenal dysregulation.