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Diurnal Cortisol Profile Modulation

Meaning

Diurnal Cortisol Profile Modulation is the clinical practice of intentionally adjusting lifestyle factors and, if necessary, targeted supplements to restore a healthy 24-hour pattern of cortisol release. The ideal profile features a sharp morning peak, a gradual decline throughout the day, and a nadir before sleep, which is critical for maintaining energy, immune function, and stress resilience. Dysregulation of this rhythm is a common sign of chronic stress or HPA axis dysfunction.