What is the Origin of Diurnal Cortisol Patterns?

The term combines "diurnal," meaning occurring during the day, with "cortisol," the hormone being measured, reflecting the circadian rhythm of its secretion. The concept emerged from foundational endocrinology studies that established the temporal nature of steroid hormone release.

What is the Mechanism of Diurnal Cortisol Patterns?

The pattern is centrally regulated by the suprachiasmatic nucleus (SCN), the body's master clock, which orchestrates the HPA axis's pulsatile release of cortisol. The SCN signals the hypothalamus to initiate the cascade, leading to the adrenal glands' timed production of the hormone. This programmed rhythm is necessary to prepare the body metabolically for the waking state, regulate immune surveillance, and synchronize the sleep-wake cycle.

Diurnal Cortisol Patterns

Meaning

Diurnal Cortisol Patterns describe the characteristic, cyclical fluctuations in the circulating concentration of the stress hormone cortisol over a 24-hour period in a healthy human. This pattern is distinguished by a rapid surge immediately upon waking, known as the Cortisol Awakening Response (CAR), followed by a progressive, steady decline throughout the day, reaching its lowest point around midnight. Clinically, analyzing this pattern through salivary or serum testing is essential for evaluating the functionality of the Hypothalamic-Pituitary-Adrenal (HPA) axis.

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Can a Wellness Program Negatively Affect My Thyroid and Adrenal Glands?

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Diurnal Cortisol Patterns

Meaning

Origin

Mechanism

How Do Court Rulings Shape Wellness Program Design?

Are There Specific Biomarkers Indicating Lifestyle-Induced Hormonal Imbalance Requiring Intervention?

Can a Wellness Program Negatively Affect My Thyroid and Adrenal Glands?

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