What is the Origin of Disease Susceptibility?

This term has its foundation in epidemiology, genetics, and public health, where "susceptibility" denotes a lack of resistance to a pathogen or disease process. In the context of longevity and hormonal health, the term is expanded to encompass the genetic and hormonal factors that increase the vulnerability to chronic, age-related diseases. It is a key metric in modern preventative medicine.

What is the Mechanism of Disease Susceptibility?

At a molecular level, susceptibility is driven by the presence of specific genetic variants, such as single nucleotide polymorphisms (SNPs), that influence the efficiency of metabolic pathways, immune response, or hormone receptor function. For example, variations in genes governing detoxification or inflammation can increase risk. Hormonal imbalances, such as chronic hypercortisolemia or low thyroid function, further contribute by compromising systemic resilience and repair mechanisms, thus increasing overall vulnerability.

Disease Susceptibility ∞ Area

Disease Susceptibility

Meaning

Disease Susceptibility is a clinical and genetic concept describing the inherent, often quantifiable, likelihood of an individual developing a specific pathology due to the interplay of genetic predispositions, epigenetic factors, and environmental exposures. This is not a diagnosis of disease but rather an assessment of risk based on biological and lifestyle data. Understanding one’s susceptibility allows for proactive, personalized preventative strategies to modify the trajectory of health.