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Directed Cellular Programming

Meaning

Directed Cellular Programming is a sophisticated biomedical strategy involving the precise application of specific molecular cues, including transcription factors, microRNAs, and exogenous ligands, to guide the differentiation or reprogramming of a somatic cell toward a desired cell type or functional state. This technique leverages the inherent plasticity of the cellular epigenome to alter gene expression patterns in a controlled manner, effectively changing the cell’s identity or functional profile. In the context of longevity, this is pivotal for generating replacement tissues or reversing age-related cellular senescence, offering a pathway to restore youthful physiological function.