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Direct Growth Hormone

Meaning

Direct Growth Hormone (GH) refers to the immediate, non-mediated effects of the growth hormone molecule on target tissues, distinct from the actions mediated by Insulin-like Growth Factor 1 (IGF-1). These direct actions typically involve binding to specific GH receptors on cells in adipose tissue, muscle, and liver, influencing metabolism. Clinically, this distinction is important when assessing the full spectrum of GH’s anabolic and lipolytic effects on body composition and energy balance.