What is the Origin of Dilated Cardiomyopathy?

The term is derived from Greek words: diastole meaning "dilation," kardio meaning "heart," myos meaning "muscle," and pathos meaning "disease." Its origin is purely descriptive, reflecting the observable pathology of an enlarged and weakened heart muscle. In the context of endocrinology, it relates to the cardiotoxic effects observed in states of severe, uncorrected hormone dysregulation.

What is the Mechanism of Dilated Cardiomyopathy?

Hormonally, the mechanism involves chronic stress-induced neurohormonal activation, specifically the sustained release of catecholamines and the activation of the Renin-Angiotensin-Aldosterone System (RAAS). This persistent signaling leads to adverse cardiac remodeling, myocyte loss, and interstitial fibrosis. Furthermore, severe endocrine disorders like unmanaged hyperthyroidism, pheochromocytoma, or chronic growth hormone excess can directly compromise myocardial function and structure, leading to the characteristic ventricular dilation and contractile dysfunction.

Dilated Cardiomyopathy ∞ Area

Dilated Cardiomyopathy

Meaning

Dilated Cardiomyopathy is a clinical condition of the heart muscle characterized by the dilation and enlargement of the left ventricle, or sometimes both ventricles, leading to impaired systolic function and reduced cardiac output. This progressive disease compromises the heart’s ability to pump blood efficiently, often resulting in congestive heart failure. While many causes exist, hormonal imbalances and chronic neurohormonal overactivation can be significant contributing or exacerbating factors.