Question 1

What is the Meaning of dihomo-15d-PGJ2?

Accepted Answer

Dihomo-15d-PGJ2, or dihomo-15-deoxy-Δ12,14-prostaglandin J2, is a specialized, bioactive lipid molecule belonging to the prostaglandin family of oxylipins, which are derivatives of adrenic acid. This molecule is specifically synthesized and accumulated at high levels intracellularly within senescent cells, where it actively contributes to reinforcing the state of irreversible growth arrest. Its detection and release into the circulation following intervention are emerging as a novel metabolic biomarker in geroscience and longevity research.

Question 2

What is the Origin of dihomo-15d-PGJ2?

Accepted Answer

The term is purely chemical, denoting its structure as a derivative of prostaglandin D2, with 'dihomo' indicating an elongation of the fatty acid chain compared to its more common analog, 15d-PGJ2. Its biological significance was recently established in studies of cellular senescence, providing a specific molecular signature for this aging-related cell state. This discovery offered a crucial, quantifiable indicator for the efficacy of senolytic therapies.

Question 3

What is the Mechanism of dihomo-15d-PGJ2?

Accepted Answer

Within senescent cells, dihomo-15d-PGJ2 acts as an intracellular signaling lipid that promotes and stabilizes the senescence-associated secretory phenotype (SASP) and the permanent cell cycle arrest characteristic of these aged cells. It is thought to exert its effects by activating key cellular pathways, potentially including the RAS/p53 feedback loop, thereby sustaining the non-proliferative state. Critically, its release from the cell upon targeted senolytic drug administration allows it to be measured in plasma or urine, functioning as a non-invasive indicator of senolysis in a living system.

dihomo-15d-PGJ2

Meaning

Origin

Mechanism

What Are the Emerging Biomarkers for Monitoring Senolytic Therapy Effectiveness?

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