What is the Origin of Dihexa Synaptic Formation?

The term originates from the discovery and characterization of the peptide Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) at Washington State University, initially as a highly stable and potent analogue of the HGF active site. The term "Synaptic Formation" describes the desired biological outcome of its potent neurogenic activity. This development represents a significant advancement in the pharmacology of neuroplasticity.

What is the Mechanism of Dihexa Synaptic Formation?

Dihexa exerts its function by binding to the c-Met receptor, the high-affinity receptor for HGF, which is widely expressed in the central nervous system. Activation of c-Met initiates a powerful intracellular signaling cascade, including the MAPK and PI3K pathways, which rapidly stimulate the outgrowth of neurites and the formation of new dendritic spines. This molecular cascade directly drives the physical restructuring of neural circuits, leading to measurable enhancements in cognitive function and memory recall.

Dihexa Synaptic Formation

Meaning

Dihexa Synaptic Formation refers to the process of stimulating the creation of new synapses—the crucial connection points between neurons—in the brain, mediated by the potent neurotrophic compound Dihexa. This process, known as synaptogenesis, is fundamental to learning, memory consolidation, and cognitive repair following injury or age-related atrophy. Dihexa, a small peptide, acts as a highly effective agonist for the Hepatocyte Growth Factor (HGF) receptor, thereby powerfully mimicking and exceeding the effects of its natural counterpart, brain-derived neurotrophic factor (BDNF).