Dihexa Peptide Therapy involves the clinical administration of Dihexa, an orally active, small-molecule peptide derivative of angiotensin IV, utilized for its potent neurotrophic and cognitive-enhancing properties. This therapy is employed to support neurological health, improve memory consolidation, and enhance synaptic function, particularly in contexts where brain-derived neurotrophic factor (BDNF) signaling is compromised. It represents a targeted pharmacological approach to neuro-optimization and longevity, supporting the brain’s structural resilience.
Origin
Dihexa originated from extensive research into the renin-angiotensin system, specifically the non-pressor effects of angiotensin IV and its potential for neuroprotection and cognitive enhancement. Developed as a highly potent agonist for the hepatocyte growth factor (HGF) receptor, c-Met, its therapeutic application reflects a modern shift toward using small peptides to directly influence critical growth factor pathways in the central nervous system. The term “therapy” indicates its structured use within clinical protocols.
Mechanism
The primary mechanism of action is its high-affinity binding and powerful activation of the c-Met receptor, which is the primary receptor for HGF. Activation of c-Met initiates a powerful intracellular signaling cascade that mimics and significantly amplifies the effects of BDNF, promoting robust synaptogenesis and neuronal survival. This potentiation of neurotrophic signaling enhances the density of dendritic spines, fundamentally improving the brain’s capacity for learning and memory consolidation.
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