What is the Origin of Dihexa Peptide Mechanism?

Dihexa was developed through research into the non-pressor roles of the Renin-Angiotensin System, specifically the Angiotensin IV receptor's unexpected involvement in memory formation and synaptic plasticity. The molecule was engineered to be a stable, highly bioavailable analog that could effectively cross the blood-brain barrier to exert its therapeutic effects directly in the central nervous system.

What is the Mechanism of Dihexa Peptide Mechanism?

Dihexa functions as a high-affinity ligand for the Hepatocyte Growth Factor (HGF) receptor, also known as c-Met, thereby mimicking and dramatically amplifying the natural effects of HGF. This powerful receptor activation stimulates synaptogenesis, which is the formation of new synaptic connections, and promotes neurogenesis, the creation of new brain cells. The net result is a significant increase in synaptic density and the potentiation of long-term potentiation, supporting memory, learning, and overall brain health.

Dihexa Peptide Mechanism ∞ Area

Dihexa Peptide Mechanism

Meaning

Dihexa Peptide Mechanism describes the specific biological mode of action of Dihexa, a potent, synthetic peptide derivative of Angiotensin IV. This hexapeptide is primarily recognized for its profound neurotrophic and cognitive-enhancing properties, demonstrating a unique capacity to influence the structural and functional integrity of the brain. Understanding its mechanism is key to leveraging its potential for neuro-restoration.