Dihexa is a synthetic, orally active peptide analog derived from angiotensin IV, an active metabolite of the hormone angiotensin II, which is part of the renin-angiotensin system. Clinically, it is being investigated as a potential cognitive enhancer, or nootropic, due to its potent neurotrophic properties. The molecule is noted for its exceptional ability to cross the blood-brain barrier and stimulate synaptic plasticity and the formation of new neuronal connections. While still largely in the research phase, its mechanism of action offers a compelling avenue for addressing age-related cognitive decline and neurological health.
Origin
The peptide was developed in the early 2000s by researchers at Washington State University as part of an effort to create stable, potent compounds that could mimic or enhance the effects of the naturally occurring angiotensin IV. The name “Dihexa” is a laboratory designation reflecting its chemical structure and composition. Its origin is purely synthetic, designed to leverage a known physiological pathway for therapeutic benefit.
Mechanism
Dihexa operates primarily by binding with high affinity to the Hepatocyte Growth Factor (HGF) receptor, also known as c-Met, which is widely expressed in the central nervous system. This binding dramatically potentiates the activity of HGF, a powerful neurotrophic factor, effectively increasing its signaling cascade by several orders of magnitude. The downstream effect is a significant promotion of synaptogenesis, dendritic branching, and neuronal survival, processes crucial for memory consolidation and overall brain resilience. This mechanism offers a distinct pathway for neuro-restoration compared to traditional hormonal or neurotransmitter-based interventions.
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