Dihexa Nootropic Effects refer to the cognitive-enhancing properties of the small peptide Dihexa, specifically its capacity to improve memory, learning, and executive function in the central nervous system. This synthetic compound is classified as a nootropic, meaning it is purported to enhance intellectual performance, primarily through its potent agonism of the Hepatocyte Growth Factor (HGF) receptor, MET. Its therapeutic application is explored in neurodegenerative and cognitive decline conditions.
Origin
Dihexa was developed through rational drug design at Washington State University, stemming from research into the active site of the naturally occurring neurotrophic factor, Brain-Derived Neurotrophic Factor (BDNF). The term ‘nootropic’ itself was coined from the Greek words nous (mind) and trepein (to bend or turn), signifying its mind-modulating action.
Mechanism
The core mechanism of action involves Dihexa binding with high affinity to the MET receptor, which is the receptor for HGF. This binding stimulates the activation of the MET signaling cascade, leading to a significant increase in synaptogenesis and the formation of new functional neuronal connections. This potent neurotrophic activity is considered to be significantly greater than that of BDNF itself, facilitating neuronal repair and cognitive enhancement.
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