Dihexa Application refers to the therapeutic or investigative utilization of the small-molecule peptide Dihexa, which is a potent analog of Angiotensin IV. Its primary application is centered on promoting enhanced cognitive function, memory consolidation, and overall neurological health due to its powerful neurotrophic properties. This compound is under investigation for its potential to address age-related cognitive decline.
Origin
Dihexa was developed through targeted research into the non-pressor effects of the renin-angiotensin system within the central nervous system, specifically focusing on the parent peptide Angiotensin IV. Its creation is a product of modern peptide chemistry, aiming to isolate and amplify specific cognitive and neurogenic benefits while avoiding cardiovascular effects.
Mechanism
The peptide functions by exhibiting an extremely high affinity for the Hepatocyte Growth Factor (HGF) receptor, also known as c-Met, which is widely expressed in the brain. Activation of the HGF/c-Met signaling pathway is a robust stimulus for synaptogenesis, the formation of new synaptic connections, and neuronal differentiation. This mechanism provides a powerful, targeted means of enhancing synaptic plasticity and supporting the growth and survival of functional neural circuits.
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