What is the Meaning of Dihexa?

Dihexa is a synthetic, orally active small peptide derived from a fragment of the Angiotensin IV molecule, currently investigated in clinical research for its potent neurotrophic and cognitive-enhancing properties. It is notable for its ability to cross the blood-brain barrier and significantly stimulate synaptic connections. This compound represents a novel class of therapeutic agents for neurological health.

What is the Origin of Dihexa?

Dihexa was developed from research into the renin-angiotensin system, specifically focusing on the non-pressor cognitive effects of Angiotensin IV. Its name is a contraction reflecting its chemical structure as a dipeptide derivative. The compound's development is part of a scientific effort to create targeted agents that can promote neural repair and plasticity.

What is the Mechanism of Dihexa?

The primary mechanism of Dihexa involves potently enhancing the biological activity of Hepatocyte Growth Factor (HGF) by binding with high affinity to its receptor, c-Met. This potentiation dramatically stimulates synaptogenesis, the formation of new synapses, and neurogenesis, the creation of new neurons. This robust action on neural growth factors is the key mechanism by which Dihexa supports memory consolidation and potentially reverses neurological decline.

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