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Dietary Signaling Fidelity

Meaning

The precision and accuracy with which ingested macronutrients and micronutrients transmit metabolic and hormonal instructions to cellular receptors and genetic transcription factors. High fidelity ensures that dietary input results in the intended biochemical response, such as efficient insulin signaling or appropriate activation of nutrient-sensing pathways like mTOR and AMPK. Low fidelity results in metabolic noise and cellular miscommunication.