Dietary iron absorption is the physiological process by which iron from ingested food is taken up by the cells lining the gastrointestinal tract, primarily the duodenum, and enters the bloodstream for distribution throughout the body.
Context
This process occurs within the digestive system and is tightly regulated to maintain iron homeostasis. It is influenced by the form of iron in the diet (heme vs. non-heme) and the presence of other dietary components.
Significance
Adequate dietary iron absorption is essential for preventing iron deficiency, a common nutritional deficiency that can lead to anemia and impair physical and cognitive function. Conversely, excessive absorption can lead to iron overload and toxicity.
Mechanism
Heme iron from animal sources is absorbed more efficiently via specific transporters. Non-heme iron absorption is influenced by factors like vitamin C (enhances absorption) and phytates or polyphenols (inhibit absorption). The hormone hepcidin plays a central role in regulating iron absorption by controlling the expression of the iron exporter ferroportin.
Application
Understanding dietary iron absorption informs nutritional guidance for individuals at risk of deficiency (e.g., menstruating women, vegetarians) or those with conditions affecting absorption. It guides recommendations for iron-rich foods and supplements.
Metric
Iron absorption is indirectly assessed by measuring iron status biomarkers such as serum ferritin, transferrin saturation, hemoglobin, and red blood cell indices. Direct measurement is complex and typically reserved for research settings.
Risk
Factors impairing absorption can lead to iron deficiency anemia. Conditions affecting the gastrointestinal tract, such as celiac disease or inflammatory bowel disease, can compromise absorption. Certain medications can also interfere with iron uptake.
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