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Diacylglycerol

Meaning

Diacylglycerol (DAG) is a lipid molecule composed of a glycerol backbone esterified to two fatty acid chains, serving as a crucial second messenger in numerous cellular signaling pathways. This molecule is a key intermediate in the synthesis of triglycerides and phospholipids, playing a vital role in lipid metabolism and storage. In the context of hormonal health, elevated intracellular DAG levels are strongly implicated in the development of insulin resistance by interfering with insulin signaling cascades. Its dual role as a signaling molecule and a metabolic intermediate highlights its central position in cellular physiology.