Question 1

What is the Meaning of Diabetogenic?

Accepted Answer

Diabetogenic is a clinical and physiological descriptor for any substance, condition, or factor that tends to produce or promote the development of diabetes mellitus or a state of significant insulin resistance and glucose intolerance. This term highlights the capacity of certain hormones, medications, or pathological states to disrupt normal glucose homeostasis. For example, excess growth hormone or cortisol are classic diabetogenic hormones because they strongly oppose the action of insulin at the cellular level. Identifying diabetogenic influences is crucial for preventive health and metabolic risk stratification, especially in patients with pre-existing risk factors.

Question 2

What is the Origin of Diabetogenic?

Accepted Answer

The term is a compound adjective formed from the Greek diabetes, meaning a siphon or passing through, referring to the excessive urination characteristic of the disease, and -genic, derived from genes, meaning producing or generating. This clinical descriptor has been used since the early 20th century, particularly in endocrinology, to categorize agents that interfere with carbohydrate metabolism. It accurately labels the ability of a substance to induce a state that mimics or progresses toward clinical diabetes.

Question 3

What is the Mechanism of Diabetogenic?

Accepted Answer

A diabetogenic agent primarily operates by two key mechanisms: significantly increasing hepatic glucose output, a process known as gluconeogenesis, and inducing peripheral insulin resistance in muscle and adipose tissue. Hormones like cortisol achieve this by binding to intracellular glucocorticoid receptors, which then modulate gene expression to promote the breakdown of protein and fat into substrates for glucose production. Simultaneously, these agents impair the insulin signaling cascade, preventing glucose transporters from effectively moving glucose from the bloodstream into the cells, thereby elevating systemic blood sugar levels.

Diabetogenic

Meaning

Origin

Mechanism

Can Growth Hormone Peptide Therapy Influence Glucose Metabolism in Non-Deficient Individuals?

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