What is the Origin of Diabetes Prevention Program (DPP)?

The term originates from the multi-center randomized clinical trial sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in the United States, which began in 1996. This foundational study established the evidence base for structured, non-pharmacological interventions in endocrinology and public health. The positive outcomes led to the development of national prevention programs based on the DPP curriculum.

What is the Mechanism of Diabetes Prevention Program (DPP)?

The DPP operates by addressing the primary drivers of insulin resistance and beta-cell dysfunction. Participants work toward a goal of losing 7% of their body weight and engaging in 150 minutes of moderate-intensity physical activity per week. This combined approach enhances insulin sensitivity in peripheral tissues and reduces the metabolic strain on the pancreas, effectively normalizing glucose homeostasis and preventing the progression from prediabetes to overt type 2 diabetes.

Diabetes Prevention Program (DPP)

Meaning

The Diabetes Prevention Program, or DPP, is a landmark clinical research study and subsequent lifestyle intervention model designed to prevent or delay the onset of type 2 diabetes in high-risk individuals. It demonstrated that intensive lifestyle changes are significantly more effective than pharmacological treatment alone in reducing diabetes incidence. The program emphasizes moderate weight loss and regular physical activity as core components for metabolic health improvement.