What is the Origin of DHEA Supplementation Science?

The science emerged from the discovery of DHEA as the most abundant circulating steroid hormone and the subsequent observation of its significant decline with age, a phenomenon termed adrenopause. Research efforts then focused on DHEA replacement therapy as a strategy for healthspan and vitality.

What is the Mechanism of DHEA Supplementation Science?

Supplementation aims to restore DHEA and DHEA-S levels to a more youthful range. The administered DHEA serves as a substrate for peripheral steroidogenic enzymes, allowing target tissues to locally synthesize active sex steroids like testosterone and estrogen via the intracrine pathway. This targeted mechanism bypasses systemic feedback loops more effectively than direct sex hormone administration, supporting endocrine balance and influencing various cellular functions, including gene expression and immune response.

DHEA Supplementation Science

Meaning

This encompasses the clinical and biochemical research dedicated to understanding the safe, effective, and precise use of dehydroepiandrosterone (DHEA) supplementation to address age-related decline or deficiency in endogenous DHEA levels. The science focuses on determining optimal dosing, administration routes, and monitoring protocols to achieve desired physiological outcomes, such as improved bone density, mood, and hormonal balance, while mitigating potential side effects.