What is the Origin of DHEA Supplementation Protocol?

DHEA is one of the most abundant circulating steroids in the human body, and its dramatic decline with age is a recognized phenomenon termed adrenopause. The supplementation protocol originated from clinical research suggesting that restoring these youthful levels could mitigate certain age-related symptoms. It is a well-established practice within anti-aging and functional endocrinology to address a known physiological deficiency.

What is the Mechanism of DHEA Supplementation Protocol?

Exogenous DHEA functions as a prohormone, serving as a vital substrate for the peripheral synthesis of other sex steroids, including testosterone and various estrogens, within target tissues. The protocol aims to safely increase the availability of these downstream hormones, potentially enhancing bone density, libido, mood, and immune function. Close, regular clinical monitoring of DHEA sulfate (DHEA-S) and related metabolites is essential to ensure efficacy and prevent supraphysiological concentrations.

DHEA Supplementation Protocol

Meaning

A DHEA Supplementation Protocol is a clinically managed regimen involving the exogenous administration of dehydroepiandrosterone (DHEA), a precursor hormone synthesized by the adrenal glands. This protocol is typically implemented to address the age-related decline in DHEA production or to correct specific endocrine imbalances identified through diagnostic testing. The objective is to restore DHEA levels to a therapeutic range, thereby supporting overall hormonal synthesis and well-being.