What is the Origin of DHEA Supplementation Benefits?

DHEA was first isolated in the 1930s, and its role as a key adrenal precursor hormone has been understood for decades. Interest in DHEA supplementation for anti-aging purposes surged after the recognition of its age-related decline, leading to extensive research into its pleiotropic effects on human health.

What is the Mechanism of DHEA Supplementation Benefits?

DHEA itself is a weak androgen but primarily functions as a prohormone, serving as the most abundant circulating precursor for both testosterone and estrogens in peripheral tissues, especially after menopause or andropause. Its benefits are realized through both its direct action on cellular receptors and the downstream conversion into more potent sex steroids. It also modulates immune function and acts as a neurosteroid, influencing brain health and mood regulation.

DHEA Supplementation Benefits

Meaning

The physiological advantages observed from the exogenous administration of Dehydroepiandrosterone (DHEA), a steroid hormone precursor produced primarily by the adrenal glands, which typically declines with age. Documented benefits, often seen in individuals with documented low DHEA levels, include support for bone density, improved sexual function, enhanced mood, and modest improvements in body composition. Clinical use requires careful monitoring due to its conversion into androgens and estrogens.