Question 1

What is the Meaning of DHEA-Sulfate (DHEAS)?

Accepted Answer

DHEA-Sulfate (DHEAS) is the stable, sulfated form of dehydroepiandrosterone (DHEA), which functions as a major steroid hormone primarily synthesized and secreted by the adrenal glands. As a critical precursor, DHEAS is the most abundant circulating steroid hormone in the human body, serving as a large, systemic reservoir for the subsequent synthesis of both androgens and estrogens in various peripheral tissues. Its circulating concentration exhibits a characteristic decline with advancing age, leading to its clinical utility as a reliable biomarker of adrenal function, overall vitality, and the biological aging process. DHEAS levels are frequently monitored in the clinical assessment of hormonal health and in the context of age-related endocrine decline.

Question 2

What is the Origin of DHEA-Sulfate (DHEAS)?

Accepted Answer

DHEA was initially isolated in the 1930s, but its sulfated form, DHEAS, was later correctly identified as the dominant, more water-soluble, and significantly more stable circulating metabolite. The name is a direct contraction of the full chemical name, accurately reflecting its structure as an adrenal-derived steroid molecule with a sulfate group attached at the C3 position. Its fundamental role as a major precursor in the overall steroidogenesis pathway was fully elucidated through decades of rigorous endocrine research, which mapped the complex metabolic conversions occurring in the adrenal cortex and throughout peripheral tissues.

Question 3

What is the Mechanism of DHEA-Sulfate (DHEAS)?

Accepted Answer

The conversion of DHEA to DHEAS is efficiently catalyzed by the enzyme sulfotransferase, primarily in the adrenal glands and the liver, a process that makes it highly water-soluble and confers a prolonged plasma half-life. DHEAS effectively functions as an inactive storage form that can be readily desulfated back to the active DHEA by the enzyme steroid sulfatase within target tissues, including the skin, fat, and the brain. Once locally converted back to DHEA, it can then be further metabolized into more potent sex steroids like testosterone and estradiol, thereby exerting its specific biological effects locally in a paracrine or intracrine manner.

DHEA-Sulfate (DHEAS)

Meaning

Origin

Mechanism

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