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DHEA Signaling Pathways

Meaning

DHEA signaling pathways describe the complex, multi-faceted mechanisms through which Dehydroepiandrosterone and its sulfated form, DHEA-S, exert their widespread effects on cellular function throughout the body. These pathways encompass both direct, independent receptor binding and the critical peripheral conversion of DHEA into more potent sex steroids, such as testosterone and estrogen. The resulting signaling cascades initiated by DHEA are vital for modulating immune function, neuroprotection, metabolic balance, and maintaining skin integrity. Understanding these distinct pathways is essential for fully appreciating the pleiotropic, life-sustaining actions of this adrenal precursor hormone.