What is the Origin of DHEA Signaling?

The concept arises from steroid biochemistry and endocrinology, where DHEA was identified as the most abundant circulating steroid hormone, primarily produced by the adrenal glands. Its significance became clearer as researchers mapped its downstream metabolic conversions. It is central to understanding adrenal androgen function.

What is the Mechanism of DHEA Signaling?

DHEA signaling involves its direct interaction with nuclear receptors or its conversion into testosterone and estrogen via local tissue enzymes, bypassing the traditional gonadal pathway. Furthermore, DHEA acts as a positive allosteric modulator at GABA receptors in the central nervous system, influencing neural signaling integrity. This dual action highlights its role in both systemic hormonal balance and neurological function.

DHEA Signaling

Meaning

DHEA Signaling refers to the complex network of actions mediated by Dehydroepiandrosterone (DHEA) and its sulfated form (DHEA-S) throughout the body, which functions as a precursor to sex hormones and has independent neurosteroid effects. Understanding this signaling is key to assessing adrenal and gonadal reserve, especially in aging populations. Optimal signaling supports energy metabolism and cognitive function.