What is the Origin of DHEA-S Restoration?

The term is derived from the steroid hormone DHEA, which is sulfated in the adrenal gland and liver to form DHEA-S, and "Restoration," meaning the act of bringing something back to its former condition. The clinical practice of DHEA-S replacement therapy emerged from extensive endocrinological research documenting the profound age-related decrease in this adrenal androgen precursor. Its origin is firmly rooted in the understanding of the adrenopause, the gradual decline in adrenal androgen production over time.

What is the Mechanism of DHEA-S Restoration?

The mechanism of restoration involves the exogenous administration of DHEA, which is then readily sulfated in the liver and adrenal glands to become DHEA-S, the primary circulating form. Once restored to physiological levels, DHEA-S acts as a reservoir, converting locally in target tissues—such as the skin, brain, and immune cells—into active sex steroids like testosterone and estradiol, as needed. This local conversion bypasses systemic fluctuations, exerting paracrine effects that support neuroprotection, immune modulation, and the maintenance of lean body mass.

DHEA-S Restoration

Meaning

DHEA-S Restoration is the clinical strategy focused on safely and physiologically raising the circulating levels of Dehydroepiandrosterone Sulfate back to an optimal range, typically seen in healthy young adulthood. DHEA-S is a crucial adrenal steroid and a precursor to both androgens and estrogens, declining significantly with age. This restoration aims to mitigate the adverse effects of its age-related decline, such as diminished energy, compromised immune function, and reduced bone density. It is a fundamental component of comprehensive hormonal health and anti-aging protocols.

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