What is the Origin of DHEA-S Replenishment Protocols?

This practice stems from the observation in endocrinology that DHEA-S levels decline predictably and significantly with age, leading to a state termed adrenopause. The protocol development is rooted in the physiological understanding of the adrenal cortex's production of DHEA, combined with clinical trials investigating the health effects of DHEA supplementation. It is a targeted intervention within the broader field of hormonal optimization.

What is the Mechanism of DHEA-S Replenishment Protocols?

DHEA is primarily sulfated in the adrenal glands and liver to DHEA-S, the most abundant circulating steroid hormone. Replenishment protocols work by providing the precursor molecule, which is then converted peripherally into androgens and estrogens as needed by target tissues. Maintaining optimal DHEA-S levels supports immune function, bone density, and neurological health by ensuring adequate substrate availability for downstream steroid hormone synthesis and action.

DHEA-S Replenishment Protocols ∞ Area

DHEA-S Replenishment Protocols

Meaning

DHEA-S Replenishment Protocols are clinically supervised treatment plans specifically designed to restore circulating levels of Dehydroepiandrosterone sulfate (DHEA-S) to a range associated with youthful vitality and endocrine function. These protocols often involve the administration of exogenous DHEA to support adrenal and gonadal steroidogenesis. The therapeutic goal is to mitigate age-related decline in DHEA-S, which is a crucial precursor to sex hormones and a neurosteroid.