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DHEA-S Replenishment

Meaning

DHEA-S Replenishment is the targeted therapeutic strategy of administering Dehydroepiandrosterone (DHEA) or its sulfated form to restore circulating levels to a youthful or optimal physiological range. This intervention is clinically indicated for individuals presenting with documented low DHEA-S status, often associated with age-related decline or adrenal dysfunction. The goal is to safely increase the prohormone pool, thereby supporting downstream synthesis of sex steroids, enhancing immune function, and improving bone mineral density. Precise dosing and careful monitoring of potential metabolic conversion are critical for successful replenishment and patient safety.