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DHEA-S Replacement Strategy

Meaning

DHEA-S Replacement Strategy refers to the clinical approach of administering dehydroepiandrosterone sulfate (DHEA-S) to restore circulating levels to a youthful, physiological range, particularly in individuals experiencing age-related decline or adrenal insufficiency. DHEA-S is a primary adrenal androgen precursor hormone, essential for the synthesis of other sex steroids like testosterone and estrogens, and is known for its pleiotropic effects on mood, cognition, and immune function. A carefully titrated replacement strategy aims to leverage DHEA-S’s role as a metabolic buffer and neurosteroid precursor to enhance overall well-being and endocrine resilience.