What is the Origin of DHEA-S Level Assessment?

DHEA-S is a naturally occurring steroid hormone, and its assessment has been a standard part of endocrinology panels since the understanding of adrenal gland biochemistry matured. The 'S' denotes the sulfated form, which is highly stable in the bloodstream, making it a reliable indicator of long-term adrenal output. This measurement is a cornerstone of anti-aging and functional medicine evaluations.

What is the Mechanism of DHEA-S Level Assessment?

DHEA-S is synthesized primarily by the adrenal cortex under the influence of ACTH, although its secretion is less tightly regulated by the HPA axis than cortisol. Once in circulation, DHEA-S can be converted in peripheral tissues into DHEA, and subsequently into active androgens (like testosterone) or estrogens (like estradiol). The assessment reflects the functional integrity of the adrenal zona reticularis and its capacity to provide essential building blocks for other sex hormones.

DHEA-S Level Assessment ∞ Area

DHEA-S Level Assessment

Meaning

The clinical procedure of measuring the serum concentration of Dehydroepiandrosterone Sulfate (DHEA-S), the most abundant circulating adrenal steroid and a precursor to both androgens and estrogens. Assessment of this biomarker provides crucial insight into adrenal gland function, overall steroidogenesis capacity, and the body’s physiological reserve against chronic stress and aging. Optimal DHEA-S levels are often correlated with vitality, immune function, and bone density.