DHEA-S Evaluation refers to the clinical assessment of Dehydroepiandrosterone Sulfate levels, a major adrenal androgen and neurosteroid precursor, typically measured via serum or salivary testing. This evaluation provides crucial insight into adrenal function, particularly the activity of the zona reticularis, and serves as a broad indicator of overall anabolic-to-catabolic balance. DHEA-S levels naturally decline with age, making its measurement a key component in assessing biological vitality, stress adaptation capacity, and hormonal reserve. The results guide therapeutic strategies aimed at supporting adrenal health and maintaining youthful endocrine signaling.
Origin
The evaluation is rooted in classic endocrinology, stemming from the identification of DHEA-S as the most abundant circulating steroid hormone in humans. Its role as a biomarker for adrenal function was established through decades of research into adrenal disorders like congenital adrenal hyperplasia. The increasing focus on DHEA-S in wellness and longevity medicine reflects its multifaceted role as a precursor to sex hormones and a modulator of immune and cognitive function.
Mechanism
DHEA-S is produced almost exclusively by the adrenal glands, sulfated from DHEA by the enzyme sulfotransferase. Its high concentration and long half-life make it a stable, reliable proxy for overall adrenal output and the body’s capacity to generate downstream sex hormones like testosterone and estrogen in peripheral tissues. Evaluating its concentration allows clinicians to assess the chronic stress load on the adrenal axis and determine the need for precursor or lifestyle support to restore hormonal homeostasis.
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