What is the Origin of DHEA-S Adrenal Reserve Evaluation?

The evaluation is based on the established endocrinology of the adrenal glands, which are the sole significant source of DHEA-S production in the body. Clinical utility grew as practitioners recognized the importance of DHEA-S levels in relation to vitality, immune function, and age-related decline.

What is the Mechanism of DHEA-S Adrenal Reserve Evaluation?

The adrenal glands produce DHEA, which is rapidly sulfated into DHEA-S; this conversion provides a stable, high-concentration measure in the blood, reflecting sustained adrenal function. Low DHEA-S levels can indicate a reduced adrenal reserve, suggesting prolonged stress or aging has diminished the adrenals' ability to produce steroid hormones, impacting mood, energy, and hormonal homeostasis.

DHEA-S Adrenal Reserve Evaluation ∞ Area

DHEA-S Adrenal Reserve Evaluation

Meaning

DHEA-S Adrenal Reserve Evaluation is a diagnostic assessment that measures the circulating level of Dehydroepiandrosterone Sulfate (DHEA-S) to infer the functional capacity and resilience of the adrenal cortex. DHEA-S is a primary adrenal androgen precursor, and its concentration serves as a reliable, long-term biomarker of adrenal output, distinct from the pulsatile nature of cortisol. This evaluation provides crucial insight into the body’s overall anabolic-to-catabolic balance.