What is the Origin of DHEA Replenishment Therapy?

DHEA, an endogenous steroid, was identified in the 1950s, and the concept of "replenishment" arose from the observation of its significant, age-related decline, often referred to as adrenopause. The therapeutic application seeks to counteract this natural physiological decrease.

What is the Mechanism of DHEA Replenishment Therapy?

DHEA functions as a prohormone, circulating throughout the body and being converted in peripheral tissues, such as the skin and adipose tissue, into potent androgens and estrogens via the process of intracrinology. Replenishment therapy directly increases the substrate pool, allowing target tissues to locally synthesize the necessary sex steroids to maintain cellular function and tissue health.

DHEA Replenishment Therapy ∞ Area

DHEA Replenishment Therapy

Meaning

The clinical practice of administering dehydroepiandrosterone (DHEA) or its sulfate ester, DHEA-S, to individuals with documented sub-optimal levels, aiming to restore concentrations to a youthful or clinically beneficial range. This therapy is employed to support various endocrine functions, including mood, energy, immune function, and bone density, as DHEA serves as a crucial precursor to other sex steroids. Precise dosage and continuous monitoring of downstream metabolites are necessary for safety and efficacy.