What is the Origin of DHEA Replacement?

DHEA originates from the adrenal cortex, where it is synthesized from cholesterol, serving as a foundational prohormone in the peripheral endocrine cascade. The 'replacement' aspect implies supplementation to compensate for diminished endogenous production, a common observation past the third decade of life. Its etymology simply denotes its chemical structure and primary source.

What is the Mechanism of DHEA Replacement?

DHEA functions as a substrate for the enzymes 17-hydroxylase and 17,20-lyase, enabling its conversion into androgens like testosterone and estrogens in peripheral tissues. Furthermore, DHEA and its sulfate conjugate exhibit independent actions as neurosteroids, potentially influencing neuronal membrane function and mood regulation. This conversion pathway must be balanced to avoid unwanted downstream metabolite accumulation.

DHEA Replacement

Meaning

The clinical administration of Dehydroepiandrosterone (DHEA), a naturally occurring adrenal androgen precursor, typically to restore serum levels that have declined due to aging or specific pathologies. This intervention aims to support adrenal reserve and provide substrate for downstream sex hormone synthesis. It is a specific form of hormonal optimization often monitored closely via laboratory markers.