A clinical strategy focused on restoring and maintaining optimal physiological levels of the steroid hormones Dehydroepiandrosterone (DHEA) and Pregnenolone, which are vital precursors in the adrenal and gonadal steroidogenesis pathways. This optimization aims to support the production of downstream hormones, including cortisol, testosterone, and estrogens, which are essential for systemic balance. The approach is used to address symptoms associated with adrenal insufficiency or age-related hormonal decline, promoting vitality and cognitive function.
Origin
The practice emerges from advanced endocrinology, recognizing Pregnenolone as the foundational steroid synthesized from cholesterol, and DHEA as a crucial neurosteroid and adrenal androgen. The concept of “optimization” moves beyond simply treating overt deficiency to achieving levels associated with peak health and youthful endocrine function. This methodology is central to bioidentical hormone replacement therapy principles.
Mechanism
Optimization operates by supplementing or supporting the body’s endogenous production of these two foundational prohormones. Pregnenolone acts as the mother steroid, directly influencing mineralocorticoid, glucocorticoid, and sex steroid pathways. DHEA serves as a reservoir for androgen and estrogen synthesis in peripheral tissues. By ensuring adequate precursor availability, the mechanism aims to restore the entire steroid cascade, improving cellular signaling and tissue function across multiple organ systems.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.