Question 1

What is the Meaning of DHEA Neurosteroids?

Accepted Answer

DHEA Neurosteroids refers to Dehydroepiandrosterone (DHEA) and its sulfated form (DHEA-S) when they are synthesized locally within the glial cells and neurons of the central and peripheral nervous systems. Functioning as neuromodulators, these compounds exert rapid, non-genomic effects on neuronal excitability and synaptic communication, independent of their classical systemic endocrine roles. Clinically, DHEA neurosteroids are studied for their potential to support mood, stress resilience, and cognitive integrity throughout the lifespan.

Question 2

What is the Origin of DHEA Neurosteroids?

Accepted Answer

The term is a compound of the DHEA abbreviation and "neurosteroids," a classification of steroids that are synthesized in the brain and rapidly modulate neural function. This concept emerged from neuroendocrinology research in the late 20th century, which identified the capacity of the nervous system to synthesize and utilize these steroid molecules locally. This local synthesis distinguishes their action from the circulating DHEA produced primarily by the adrenal glands.

Question 3

What is the Mechanism of DHEA Neurosteroids?

Accepted Answer

As neurosteroids, DHEA and DHEA-S modulate the activity of crucial neurotransmitter receptors, notably acting as positive modulators of the inhibitory GABA-A receptor and as negative modulators of the excitatory NMDA receptor. This regulatory action helps maintain the necessary balance between neuronal excitation and inhibition, which is vital for stress adaptation and neuroprotection. Local metabolism of DHEA into other neuroactive steroids further influences synaptic plasticity and myelination, contributing to the brain's long-term functional resilience.

DHEA Neurosteroids

Meaning

Origin

Mechanism

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