What is the Origin of DHEA Neuroprotection?

The term combines the specific adrenal androgen, DHEA, with "Neuroprotection," a concept borrowed from neurology describing the preservation of nerve cell function. Its inclusion in wellness science highlights DHEA's function as a powerful endogenous antioxidant within the brain microenvironment. This protective role is paramount as systemic inflammation increases.

What is the Mechanism of DHEA Neuroprotection?

DHEA exerts its neuroprotective effect partly through direct scavenging of reactive oxygen species and by modulating the expression of anti-apoptotic genes within glial cells and neurons. It also influences the activity of NMDA receptors, helping to prevent calcium overload associated with excitotoxic neuronal damage. Proper DHEA availability supports overall cellular energy metabolism required for neuronal resilience.

DHEA Neuroprotection ∞ Area

DHEA Neuroprotection

Meaning

DHEA Neuroprotection refers to the established biological role of Dehydroepiandrosterone (DHEA) and its metabolites in safeguarding neuronal structures against oxidative stress and excitotoxicity. This protective effect is vital for preserving cognitive function over the lifespan, especially when facing chronic physiological challenges. We recognize DHEA as a crucial precursor hormone with significant downstream effects in the central nervous system. Clinical assessment often involves measuring DHEA-S levels as an indicator of adrenal reserve.