What is the Origin of DHEA Neuromodulation?

DHEA, primarily produced by the adrenal glands, has been recognized for its role in both peripheral and central nervous system health. The term 'neuromodulation' emphasizes its action not as a primary neurotransmitter, but as a steroid that alters the responsiveness of neurons to other signals, a key concept in neuroendocrinology.

What is the Mechanism of DHEA Neuromodulation?

DHEA and DHEA-S exert their effects through several mechanisms, including positive allosteric modulation of the NMDA receptor, which is critical for long-term potentiation and memory. Furthermore, DHEA-S acts as a non-competitive antagonist of the GABA-A receptor, thereby promoting a mild excitatory tone that can enhance alertness and cognitive processing. This dual action helps balance neural excitation and inhibition.

DHEA Neuromodulation

Meaning

DHEA neuromodulation describes the influence of dehydroepiandrosterone (DHEA) and its sulfated form, DHEA-S, on the excitability, plasticity, and overall function of neurons and neural circuits within the central nervous system. DHEA acts as a significant neurosteroid, directly affecting various neurotransmitter receptors and promoting neuronal survival. Its optimal level is associated with enhanced cognitive performance and protection against age-related neurodegenerative processes.