The utilization of Dehydroepiandrosterone (DHEA), a precursor steroid hormone, to promote and maintain healthy brain function, memory, and mood. DHEA is the most abundant circulating adrenal steroid, and its levels naturally decline with age, correlating with potential cognitive decline. Supplementation is employed to sustain neurosteroid levels necessary for optimal neurological health.
Origin
DHEA was first isolated in the 1930s; its role as a neurosteroid was recognized much later. The concept of “DHEA Cognitive Support” stems from clinical observations showing DHEA’s concentration in brain tissue and its direct impact on neural activity. This therapeutic application is rooted in the understanding of the neuroendocrine axis and age-related hormonal shifts.
Mechanism
DHEA and its sulfated form, DHEA-S, act as neurosteroids, modulating the activity of neurotransmitter receptors, particularly the NMDA and GABAA receptors, which are crucial for learning and memory formation. Furthermore, DHEA may exert neuroprotective effects by reducing oxidative stress and promoting neuronal survival. By influencing these pathways, DHEA helps maintain the structural and functional integrity of cognitive centers in the brain.
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